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Year 2011 - Volume 31, Number 11
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Kinetics of the humoral immune response of dogs young immunized with Leptospira interrogans, 31(11):1000-1005
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ABSTRACT.- Castro J.R., Souza M.A., Salaberry S.R.S., Guimarães E.C. & Lima-Ribeiro A.M.C. 2011. [Kinetics of the humoral immune response of dogs young immunized with Leptospira interrogans.] Cinética da resposta imune humoral de cães jovens imunizados contra Leptospira interrogans. Pesquisa Veterinária Brasileira 31(11):1000-1005. Faculdade de Medicina Veterinária, Universidade Federal de Uberlândia, Av. Ceará s/n, Bloco 2D, Sala 33, Campus Umuarama, Uberlândia, MG 38400-902, Brazil. E-mail: jack_ufu@yahoo.com.br
The objective was to analyze the humoral immune response against Leptospira interrogans using the microscopic agglutination test (MAT) in 26 young dogs, and 17 mixed breed (Group A) and nine mixed breed (Group B) of both sexes, pertaining to kennels and home environments in Uberlandia, Minas Gerais. Dogs were vaccinated with commercial inactivated polyvalent bacterin with Canicola, Grippotyphosa, Icterohaemorrhagiae and Pomona serovars. The immunization schedule was based on three immunizations. The first vaccination was performed at forty-five days of age, considered day zero, and after two boosters at intervals of thirty days each. Seven blood samples from each dog were made from time zero up to 180 days post-vaccination, at intervals of thirty days each. Titles have not been detected pre-vaccination against serovars Canicola, and Icterohaemorrhagiae Grippotyphosa on day zero. Only one dog in group A was reactive with a titer of 1:100 against Pomona in the first harvest. There was no statistical difference between the agglutinating titers between Groups A and B (p>0.05) induced by commercial vaccine used, except at harvest II (p<0.05), in which the group B presented evidence to serovar Autumnalis in all dogs evaluated, whereas in group A, 64.7% of dogs were not reactive to any serovar tested. There were on the 30th title to serovar Autumnalis that persisted until 180 days post-vaccination in both groups, varying only the intensity of immune response without significant statistical difference. To assess the efficiency of vaccine culture anti-Leptospira this research to warn the risks infection that dogs are vaccinated annually submitted. |
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