PESQUISA VETERINÁRIA BRASILEIRA

Abstract in English:

ABSTRACT.- Moura Junior P.C., Vieira T.H.M., Vieira S.R.C., Sobreiro D., Ruiz C.R., Wafae G.C., Silva N.C. & Wafae N. 2008. [Anatomic study of coronary arteries Landrace pigs.] Estudo anatômico das artérias coronárias de suínos Landrace. Pesquisa Veterinária Brasileira 28(2):103-107. Laboratório de Anatomia da União Educacional do Planalto Central, Campus II, Área Especial nº 2, Setor Leste, Gama, DF 72460-000, Brazil. E-mail: crisruiz@scamilo.edu.br The experimental use of coronary arteries of swine to study drug action for clinical and surgical application is an important tool. For this anatomic study about coronary arteries, thirty hearts of Landrace pigs, of both sexes, 5 to 6 months old, weighing 80 to 110 kg, were fixed in 10% formalin. The coronary arteries and their branches were dissected until the visible ramifications. There was one left coronary artery, with length of 0.4-1.2cm, giving off 2 (80%) or 3 (20%) branches. The paraconal interventricular branch, with length of 10-16cm, emitted 16-25 branches, 52.3% for the right ventricle and 47.7% for the left ventricle. The circumflex branch, with length of 7-15cm, emitted 4-13 branches, 55.6% for the left ventricle and 44.4% for the left atrium. There was one right coronary artery, with length of 7.5-11.5cm, which emitted 12-21 branches, 57.4% for the right ventricle and 42.6% for the right atrium. The subsinuosus interventricular branch, length of 3-11cm, emitted 9-22 branches, 50.9% for the right ventricle and 49.1% for the left ventricle. The number of branches of the paraconal interventricular branch and the number of branches of the subsinuosus interventricular branch was similar for both ventricles. The results obtained in the present study compared with the literature indicate that the distribution of the coronary branches in swine and in humans is similar.

• Coronary artery anatomy swine heart

Abstract in Portuguese:

ABSTRACT.- Moura Junior P.C., Vieira T.H.M., Vieira S.R.C., Sobreiro D., Ruiz C.R., Wafae G.C., Silva N.C. & Wafae N. 2008. [Anatomic study of coronary arteries Landrace pigs.] Estudo anatômico das artérias coronárias de suínos Landrace. Pesquisa Veterinária Brasileira 28(2):103-107. Laboratório de Anatomia da União Educacional do Planalto Central, Campus II, Área Especial nº 2, Setor Leste, Gama, DF 72460-000, Brazil. E-mail: crisruiz@scamilo.edu.br The experimental use of coronary arteries of swine to study drug action for clinical and surgical application is an important tool. For this anatomic study about coronary arteries, thirty hearts of Landrace pigs, of both sexes, 5 to 6 months old, weighing 80 to 110 kg, were fixed in 10% formalin. The coronary arteries and their branches were dissected until the visible ramifications. There was one left coronary artery, with length of 0.4-1.2cm, giving off 2 (80%) or 3 (20%) branches. The paraconal interventricular branch, with length of 10-16cm, emitted 16-25 branches, 52.3% for the right ventricle and 47.7% for the left ventricle. The circumflex branch, with length of 7-15cm, emitted 4-13 branches, 55.6% for the left ventricle and 44.4% for the left atrium. There was one right coronary artery, with length of 7.5-11.5cm, which emitted 12-21 branches, 57.4% for the right ventricle and 42.6% for the right atrium. The subsinuosus interventricular branch, length of 3-11cm, emitted 9-22 branches, 50.9% for the right ventricle and 49.1% for the left ventricle. The number of branches of the paraconal interventricular branch and the number of branches of the subsinuosus interventricular branch was similar for both ventricles. The results obtained in the present study compared with the literature indicate that the distribution of the coronary branches in swine and in humans is similar.

Abstract in English:

ABSTRACT.- Vasconcelos R.O., Barros S.S., Russowski D., Grando S.M. & Irigoyen L.F. 1998. Arterial diffuse intimal thickening associated with enzootic calcinosis of sheep. [Espessamento intimal difuso das artérias na calcinose enzoótica dos ovinos.] Pesquisa Veterinária Brasileira 18(1):9-15. Oepto Patologia, Universidade Federal de Santa Maria, 97119-900 Santa Maria, RS, Brazil. Morphometric, immunohistochemical and ultrastructural studies were carried out on the diffuse intimal thickening (DIT) in arteries of 7 sheep with clinical signs of naturally occurring enzootic calcinosis dueto ingestion of the plant Nierembergia veitchii. Arterial lesions consisted of medial deposition of calcium salts and DIT. Calcification of the intima was rare, mild and located near the elastic lamina. By immunohistochemistry a-actin was detected in cells of the media and in cells forming the intimal thickening. Receptors for 1,25(OH)2 vitamin O3 were detected in nuclei of intimal, medial and endothelial cells. DIT was irregularly distributed and was neither proportionally related to the intensity of the underlying mineralization area nor to the thickening of the remaining media. Ultrastructural morphometry in smooth muscle cells (SMCs) of the media and thickened intima revealed, in the latter, an increase of 318% in the volumetric fraction of those organelles involved in synthesis and a proportional decrease in contractile elements when compared to normal values of media cells. There were histological and ultrastructural evidences of modification of SMCs and their migration to the intima, where they proliferated causing DIT. It was concluded that DIT is a consistent component of arteriosclerotic lesions in N. veitchii induced calcinosis of sheep and that the predominant cell in this process is the SMCs originated from its predecessor of the media. It is suggested that the inducing factor for the arterial changes is 1,25(0H)2 03 present in N. veitchii.

• Enzootic calcinosis Nierembergia veitchii arterial lesions sheep Calcinose enzoótica lesão arterial ovinos.

Abstract in Portuguese:

RESUMO.- Vasconcelos R.O., Barros S.S., Russowski D., Grando S.M. & Irigoyen L.F. 1998. Arterial diffuse intimal thickening associated with enzootic calcinosis of sheep. [Espessamento intimal difuso das artérias na calcinose enzoótica dos ovinos.] Pesquisa Veterinária Brasileira 18(1):9-15. Oepto Patologia, Universidade Federal de Santa Maria, 97119-900 Santa Maria, RS, Brazil. Foram feitos estudos morfométrico, imunoistoquímico e ultra-estrutural do espessamento intimal difuso (DIT) das artérias de 7 ovinos com sinais clínicos de calcinose enzoótica espontânea causada pela ingestão da planta Nierembergia veitchii. As lesões caracterizavam-se por deposição de sais de cálcio na média como placas e estrias que, com frequência faziam saliência para a luz, criando rugosidades e irregularidades da íntima. Não foram observadas calcificações na artéria pulmonar e no sistema venoso. Microscopicamente, as calcificações das artérias restringiam-se quase que exclusivamente à média. Na imunoistoquimica, foi verificada a-actina nas células da média e nas do espessamento intimal. Receptores para 1,25(OH)2D3 foram evidenciados nos núcleos das células musculares da média, da íntima e das células endoteliais. As análises morfométricas em microscopia ótica revelaram, nas artérias, DIT irregularmente distribuído sem relação com a intensidade dos processos de calcificação subjacente nem com a espessura da média remanescente. A morfometria das alterações ultra-estruturais das células musculares lisas da média e da íntima espessada, m intimal ostrou que nessas últimas foi verificado aumento de até 318% na fração volumétrica das organelas de síntese em detrimento dos elementos contráteis, quando comparados com os valores das células da média. Essas modificações indicam a transformação das células musculares lisas de um tipo contrátil para células de tipo sintético. Entre essses dois extremos foram evidenciadas diversas formas intermediárias. Foram observadas evidências histológicas e ultra-estruturais da transformação e migração de células da média através das fenestras da lâmina elástica interna, para a íntima, onde proliferam e formam o DIT. Foi concluído que o DIT é um componente constante nas lesões arterioscleróticas nas calcinoses dos ovinos induzidas pela planta N. veitchii e que as células predominantes são células musculares lisas provenientes de predecessoras da média. Foi constatado que o DIT só excepcionalmente apresenta calcificação, vascularização, presença de células espumosas e fendas de colesterol. Não foram vistas áreas de necrose. Sugere-se que o fator indutor das alterações arteriais é o 1,25(OH)zD3 contido em N. veitchii.